Myo15a^tm1.1Jebd
Targeted Allele Detail

Summary

• Symbol: Myo15a^tm1.1Jebd
• Name: myosin XVA; targeted mutation 1.1, Jonathan E Bird
• MGI ID: MGI:5806093
• Synonyms: Myo15^deltaN, Myo15^E1086X
• Gene: Myo15a Location: Chr11:60360165-60419195 bp, + strand Genetic Position: Chr11, 37.81 cM
• Alliance: Myo15a^tm1.1Jebd page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:226820
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Modified isoform(s))
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: Exon 2 was replaced with a modified one in which nucleotide substitutions (GAG to TAA) results in the amino acid susbtitution of a stop codon for glutamic acid. This mutation affects isoform 1 but not isoform 2. Cre-mediated recombination removed the selection cassette. (J:226820)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Myo15a Mutation: 136 strains or lines available

References

• Original: J:226820 Fang Q, et al., The 133-kDa N-terminal domain enables myosin 15 to maintain mechanotransducing stereocilia and is essential for hearing. Elife. 2015;4
• All: 2 reference(s)