Tmprss4^tm1.2Hum
Targeted Allele Detail

Summary

• Symbol: Tmprss4^tm1.2Hum
• Name: transmembrane protease, serine 4; targeted mutation 1.2, Edith Hummler
• MGI ID: MGI:5806232
• Synonyms: Tmprss4^delta, Tmprss4^tm1.1Hum
• Gene: Tmprss4 Location: Chr9:45084024-45115390 bp, - strand Genetic Position: Chr9, 24.84 cM
• Alliance: Tmprss4^tm1.2Hum page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:229561
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S5/SvEvBrd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of exon 8. An FRT-flanked neomycin resistance cassette with a 3' loxP site was inserted downstream of exon 9. Flp-mediated recombination removed the selection cassette. Cre-mediated recombination removed exons 8 and 9. Western blot analysis confirmed the absence of protein expression in the colon. (J:229561)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Tmprss4 Mutation: 27 strains or lines available

References

• Original: J:229561 Keppner A, et al., Epithelial Sodium Channel-Mediated Sodium Transport Is Not Dependent on the Membrane-Bound Serine Protease CAP2/Tmprss4. PLoS One. 2015;10(8):e0135224
• All: 2 reference(s)