Ppp3cb^M1Btlr
Chemically induced Allele Detail

Summary

• Symbol: Ppp3cb^M1Btlr
• Name: protein phosphatase 3, catalytic subunit, beta isoform; mutation 1, Bruce Beutler
• MGI ID: MGI:5806304
• Synonyms: Copacabana
• Gene: Ppp3cb Location: Chr14:20549432-20596641 bp, - strand Genetic Position: Chr14, 11.53 cM, cytoband B
• Alliance: Ppp3cb^M1Btlr page

Mutation origin

• Strain of Origin: C57BL/6J
• Project Collection: Beutler Mutagenetix

Mutation description

• Allele Type: Chemically induced (ENU) (Not Specified)
• Mutation: Single point mutation
• Mutation details: ENU-induced A to G transition at base pair 20,530,942 (v38) on chromosome 14, or base pair 15,632 in the GenBank genomic region NC_000080. The mutation is within the donor splice site of intron 3, two base pairs from exon 3 (out of 14 total exons). The mutation is predicted to result in use of a cryptic splice site in intron 3, resulting in a 67-base pair insertion of intron 3. The insertion would result in a frame-shifted protein product beginning after amino acid 137 of the protein, which is normally 525 amino acids in length, and terminating after the inclusion of seven aberrant amino acids. (J:236670)
• Inheritance: Semidominant

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ppp3cb Mutation: 67 strains or lines available

References

• Original: J:236670 Zeng M, et al., Mutagenetix entry for Copacabana. MGI Direct Data Submission. 2016
• All: 1 reference(s)