Itk^m1Btlr
Chemically induced Allele Detail

Summary

• Symbol: Itk^m1Btlr
• Name: IL2 inducible T cell kinase; mutation 1, Bruce Beutler
• MGI ID: MGI:5806309
• Synonyms: itxaro
• Gene: Itk Location: Chr11:46215977-46280342 bp, - strand Genetic Position: Chr11, 27.75 cM
• Alliance: Itk^m1Btlr page

Mutation origin

• Strain of Origin: C57BL/6J
• Project Collection: Beutler Mutagenetix

Mutation description

• Allele Type: Chemically induced (ENU) (Not Specified)
• Mutation: Single point mutation
• Mutation details: ENU-induced A to G transition at base pair 46,338,217 (GRCm38) on chromosome 11, or base pair 51,299 in the GenBank genomic region NC_000077. The mutation corresponds to residue 1,240 in the mRNA sequence NM_001281965, within 12 of 17 exons. The mutation results in a phenylalanine to leucine substitution at position 379 (F379L) in the protein (isoform 1). (J:236673)
• Inheritance: Recessive

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Itk Mutation: 50 strains or lines available

References

• Original: J:236673 Yue T, et al., Mutagenetix entry for itxaro. MGI Direct Data Submission. 2016
• All: 1 reference(s)