Irf9^M1Btlr
Chemically induced Allele Detail

Summary

• Symbol: Irf9^M1Btlr
• Name: interferon regulatory factor 9; mutation 1, Bruce Beutler
• MGI ID: MGI:5806324
• Synonyms: Long_lost
• Gene: Irf9 Location: Chr14:55841442-55847487 bp, + strand Genetic Position: Chr14, 28.19 cM
• Alliance: Irf9^M1Btlr page

Mutation origin

• Strain of Origin: C57BL/6J
• Project Collection: Beutler Mutagenetix

Mutation description

• Allele Type: Chemically induced (ENU) (Not Specified)
• Mutation: Single point mutation
• Mutation details: ENU-induced T to C transition at base pair 55,605,910 (v38) on chromosome 14, or base pair 1,926 in the GenBank genomic region NC_000080 within the splice donor site of intron 4, six nucleotides from exon 4. The effects of the mutation at the cDNA and protein level have not examined, but the mutation is predicted to result in skipping of the 184-base pair exon 8 (out of 10 total exons). Skipping of exon 8 would result in a frame shifted protein product beginning after amino acid 126 of the protein, which is normally 465 amino acids in length, and terminating after the inclusion of 33 aberrant amino acids. (J:236674)
• Inheritance: Semidominant

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Irf9 Mutation: 40 strains or lines available

References

• Original: J:236674 Dao D, et al., Mutagenetix entry for Long_lost. MGI Direct Data Submission. 2016
• All: 1 reference(s)