Cd8a^m2Btlr
Chemically induced Allele Detail

Summary

• Symbol: Cd8a^m2Btlr
• Name: CD8 subunit alpha; mutation 2, Bruce Beutler
• MGI ID: MGI:5806327
• Synonyms: wenzhou
• Gene: Cd8a Location: Chr6:71350411-71356155 bp, + strand Genetic Position: Chr6, 32.14 cM, cytoband C
• Alliance: Cd8a^m2Btlr page

Mutation origin

• Strain of Origin: C57BL/6J
• Project Collection: Beutler Mutagenetix

Mutation description

• Allele Type: Chemically induced (ENU) (Not Specified)
• Mutation: Single point mutation
• Mutation details: ENU-induced A to T transversion at base pair 71,373,872 (v38) on chromosome 6, or base pair 446 in the GenBank genomic region NC_000072. The mutation affects nucleotide 446 of Cd8a mRNA variants 1 (NM_001081110.2) and 2 (NM_009857.1) within exon 1 of 5 total exons and exon 1 of 4 total exons, respectively. The mutation results in an aspartic acid (D) to valine (V) substitution at position 107 (D107V) of both variants. (J:236677)
• Inheritance: Recessive

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cd8a Mutation: 39 strains or lines available

References

• Original: J:236677 Zeng M, et al., Mutagenetix entry for wenzhou. MGI Direct Data Submission. 2016
• All: 1 reference(s)