Rel^M1Btlr
Chemically induced Allele Detail

Summary

• Symbol: Rel^M1Btlr
• Name: reticuloendotheliosis oncogene; mutation 1, Bruce Beutler
• MGI ID: MGI:5806335
• Synonyms: horus
• Gene: Rel Location: Chr11:23686847-23720969 bp, - strand Genetic Position: Chr11, 14.36 cM
• Alliance: Rel^M1Btlr page

Mutation origin

• Strain of Origin: C57BL/6J
• Project Collection: Beutler Mutagenetix

Mutation description

• Allele Type: Chemically induced (ENU) (Not Specified)
• Mutation: Single point mutation
• Mutation details: ENU-induced T to G transversion at base pair 23,753,215 (v38) on chromosome 11, or base pair 17,756 in the GenBank genomic region NC_000077 within the splice donor site of intron 4. The effect of the mutation at the cDNA and protein level have not examined, but the mutation is predicted to result in the use of cryptic splice site in exon 4 (out of 10 total exons) and the subsequent deletion of 71 base pair in exon 4. As a result of the deletion, there would be an in-frame deletion of 24 amino acids beginning after amino acid 108 of the encoded protein, and termination after the inclusion of two aberrant amino acids. (J:236682)
• Inheritance: Semidominant

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rel Mutation: 45 strains or lines available

References

• Original: J:236682 SoRelle J, et al., Mutagenetix entry for horus. MGI Direct Data Submission. 2016
• All: 1 reference(s)