Themis^m2Btlr
Chemically induced Allele Detail

Summary

• Symbol: Themis^m2Btlr
• Name: thymocyte selection associated; mutation 2, Bruce Beutler
• MGI ID: MGI:5806438
• Synonyms: death_valley
• Gene: Themis Location: Chr10:28544356-28759814 bp, + strand Genetic Position: Chr10, 16.06 cM
• Alliance: Themis^m2Btlr page

Mutation origin

• Strain of Origin: C57BL/6J
• Project Collection: Beutler Mutagenetix

Mutation description

• Allele Type: Chemically induced (ENU) (Not Specified)
• Mutation: Single point mutation
• Mutation details: ENU-induced A to G transition at base pair 28,668,727 (v38) on chromosome 10, or base pair 401 in the GenBank genomic region NC_000076. The mutation corresponds to residue 368 in the mRNA sequence NM_178666 within exon 1 of 6 total exons. The mutation results in an isoleucine (I) to asparagine (N) substitution at position 23 (I23N) in the protein. (J:236691)
• Inheritance: Recessive

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Themis Mutation: 57 strains or lines available

References

• Original: J:236691 Zeng M, et al., Mutagenetix entry for death_valley. MGI Direct Data Submission. 2016
• All: 1 reference(s)