Rcor2^{tm1c(EUCOMM)Wtsi}
Targeted Allele Detail

Summary

• Symbol: Rcor2^{tm1c(EUCOMM)Wtsi}
• Name: REST corepressor 2; targeted mutation 1c, Wellcome Trust Sanger Institute
• MGI ID: MGI:5806455
• Synonyms: Rcor2^fl
• Gene: Rcor2 Location: Chr19:7244759-7252590 bp, + strand Genetic Position: Chr19, 5.32 cM
• Alliance: Rcor2^{tm1c(EUCOMM)Wtsi} page
• IMPC: Rcor2 gene page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:235702
• Parent Cell Line: JM8.N4 (ES Cell)
• Strain of Origin: C57BL/6N
• Project Collection: EUCOMM

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: The L1L2_Bact_P cassette was inserted at position 7246693 of Chromosome 19 upstream of the critical exons (Build GRCm39). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. A third loxP site is inserted downstream of the targeted exon(s) at position 7249164. The critical exons are thus flanked by loxP sites. A "conditional ready" (floxed) allele was created by flp recombinase expression in mice, removing the lacZ sequence and neomycin selection cassette. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml. (J:235702)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rcor2 Mutation: 39 strains or lines available

References

• Original: J:235702 Wang Y, et al., LSD1 co-repressor Rcor2 orchestrates neurogenesis in the developing mouse brain. Nat Commun. 2016;7:10481
• All: 2 reference(s)