Zap70^m4Btlr
Chemically induced Allele Detail

Summary

• Symbol: Zap70^m4Btlr
• Name: zeta-chain (TCR) associated protein kinase; mutation 4, Bruce Beutler
• MGI ID: MGI:5806458
• Synonyms: waterfowl
• Gene: Zap70 Location: Chr1:36800912-36821899 bp, + strand Genetic Position: Chr1, 15.41 cM, cytoband A4-C1
• Alliance: Zap70^m4Btlr page

Mutation origin

• Strain of Origin: C57BL/6J
• Project Collection: Beutler Mutagenetix

Mutation description

• Allele Type: Chemically induced (ENU) (Not Specified)
• Mutation: Single point mutation
• Mutation details: ENU-induced A to G transition at base pair 36,770,811 (v38) on chromosome 1, or base pair 9,014 in the GenBank genomic region NC_000067. The mutation corresponds to residue 155 in the mRNA sequence NM_009539 within exon 2 of 13 total exons, residue 198 in the mRNA sequence NM_001289765 within exon 2 of 13, and residue 163 in the mRNA sequence NM_001289766 within exon 2 of 13 total exons. The mutation is not predicted to affect transcript variant 2 (NM_001289612), because this transcript encodes an isoform, TZK (alternatively, truncated ZAP kinase) with a shorter N-terminus compared to the other isoforms. The mutated nucleotide is indicated in red. The mutation results in a methionine (M) to valine (V) substitution at position 1 (M1V) in the protein. (J:236698)
• Inheritance: Recessive

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Zap70 Mutation: 55 strains or lines available

References

• Original: J:236698 Wang K-W, et al., Mutagenetix entry for waterfowl. MGI Direct Data Submission. 2016
• All: 1 reference(s)