Zranb1^{tm1c(EUCOMM)Hmgu}
Targeted Allele Detail

Summary

• Symbol: Zranb1^{tm1c(EUCOMM)Hmgu}
• Name: zinc finger, RAN-binding domain containing 1; targeted mutation 1c, Helmholtz Zentrum Muenchen GmbH
• MGI ID: MGI:5806462
• Synonyms: Zranb1^f
• Gene: Zranb1 Location: Chr7:132532905-132588127 bp, + strand Genetic Position: Chr7, 76.32 cM
• Alliance: Zranb1^{tm1c(EUCOMM)Hmgu} page
• IMPC: Zranb1 gene page

Mutation origin

• Mutant Cell Line: HEPD0538_8_D07
• Germline Transmission: Earliest citation of germline transmission: J:235701
• Parent Cell Line: JM8A1.N3 (ES Cell)
• Strain of Origin: C57BL/6N-A^tm1Brd
• Project Collection: EUCOMM

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion Vector: L1L2_Bact_P
• Mutation details: The L1L2_Bact_P cassette was inserted at position 132567698 of Chromosome 7 upstream of the critical exon(s) (Build GRCm39). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. A third loxP site is inserted downstream of the targeted exon(s) at position 132568709. The critical exon(s) is/are thus flanked by loxP sites. A "conditional ready" (floxed) allele was created by flp recombinase expression in mice, removing the lacZ and neomycin selection cassette. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml. (J:235701)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Zranb1 Mutation: 48 strains or lines available

References

• Original: J:235701 Jin J, et al., Epigenetic regulation of the expression of Il12 and Il23 and autoimmune inflammation by the deubiquitinase Trabid. Nat Immunol. 2016 Mar;17(3):259-68
• All: 1 reference(s)