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Aregtm2c(EUCOMM)Hmgu
Targeted Allele Detail
Summary
Symbol: Aregtm2c(EUCOMM)Hmgu
Name: amphiregulin; targeted mutation 2c, Helmholtz Zentrum Muenchen GmbH
MGI ID: MGI:5806473
Synonyms: AregFl
Gene: Areg  Location: Chr5:91287458-91296291 bp, + strand  Genetic Position: Chr5, 44.78 cM
Alliance: Aregtm2c(EUCOMM)Hmgu page
IMPC: Areg gene page
Mutation
origin
Mutant Cell Line:  HEPD0772_4_A08
Germline Transmission:  Earliest citation of germline transmission: J:224904
Parent Cell Line:  JM8A3.N1 (ES Cell)
Strain of Origin:  C57BL/6N-Atm1Brd
Project Collection: EUCOMM
Mutation
description
Allele Type:    Targeted (Conditional ready)
Mutation:    Insertion     Vector: L1L2_Pgk_P
 
Mutation detailsThe L1L2_Pgk_P cassette was inserted at position 91290869 of Chromosome 5 upstream of the critical exon 3 and 4 (Build GRCm39). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by neomycin resistance gene under the control of the PGK promoter, SV40 polyA, a second FRT site and a second loxP site. A third loxP site is inserted downstream of the targeted exon(s) at position 91292610. The critical exon 3 and 4 is thus flanked by loxP sites. A "conditional ready" (floxed) allele was created by flp recombinase expression in mice carrying this allele. Subsequent cre expression results in a knockout mouse. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml. (J:224904)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Areg Mutation:  29 strains or lines available
References
Original:  J:224904 Arpaia N, et al., A Distinct Function of Regulatory T Cells in Tissue Protection. Cell. 2015 Aug 27;162(5):1078-89
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
12/10/2024
MGI 6.24
The Jackson Laboratory