Tg(SFTPC-CD74/ROS1)125Tno
Transgene Detail

Summary

• Symbol: Tg(SFTPC-CD74/ROS1)125Tno
• Name: transgene insertion 125, Tetsuo Noda
• MGI ID: MGI:5806502
• Synonyms: CD74-ROS1
• Transgene: Tg(SFTPC-CD74/ROS1)125Tno Location: unknown
• Alliance: Tg(SFTPC-CD74/ROS1)125Tno page

Transgene origin

• Strain of Origin: C57BL/6J

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(SFTPC-CD74/ROS1)125Tno expresses 2 genes
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  CD74 (972)

  Cd74	(MGI:96534)

  human

  ROS1 (6098)

  Ros1	(MGI:97999)

• Mutation details: A CD74 exon 6 to ROS1 exon 34 fusion cDNA bearing a FLAG-tag at the N terminal is under the control of a type 2 alveolar epithelium-specific human surfactant protein-C promoter. Three lines, 125, 151, and 026 were established. Immunoblotting analysis confirmed expression of fusion-gene product in lung tissues. (J:231770)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:231770 Inoue M, et al., Mouse models for ROS1-fusion-positive lung cancers and their application to the analysis of multikinase inhibitor efficiency. Carcinogenesis. 2016 May;37(5):452-60
• All: 1 reference(s)