Sik3^tm1.1Iiis
Targeted Allele Detail

Summary

• Symbol: Sik3^tm1.1Iiis
• Name: SIK family kinase 3; targeted mutation 1.1, Masashi Yanagisawa and Hiromasa Funato
• MGI ID: MGI:5806542
• Synonyms: Sik3^tm1.1Ksak
• Gene: Sik3 Location: Chr9:45924118-46135492 bp, + strand Genetic Position: Chr9, 25.36 cM
• Alliance: Sik3^tm1.1Iiis page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:236598
• Parent Cell Line: RENKA (ES Cell)
• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Targeted (Not Specified)
• Mutations: Insertion, Single point mutation
• Mutation details: An FRT-flanked neomycin resistance cassette with a 3' loxP site was inserted upstream of exon 12. Intron 13 was modified by single point mutation (G to A) that abolishes a splice donor site and mimics the ENU mutation in Sik3^Slp. Flp-mediated recombination removed the selection cassette. (J:236598)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Sik3 Mutation: 72 strains or lines available

References

• Original: J:236598 Funato H, et al., Forward-genetics analysis of sleep in randomly mutagenized mice. Nature. 2016 Nov 17;539(7629):378-383
• All: 1 reference(s)