Tg(Slc6a11-cre/ERT2)1Khakh
Transgene Detail

Summary

• Symbol: Tg(Slc6a11-cre/ERT2)1Khakh
• Name: transgene insertion 1, Baljit Khakh
• MGI ID: MGI:5806574
• Synonyms: GAT3-Cre/ERT2 BAC, Slc6a11-Cre/ERT2 BAC
• Transgene: Tg(Slc6a11-cre/ERT2)1Khakh Location: unknown
• Alliance: Tg(Slc6a11-cre/ERT2)1Khakh page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Inducible, Recombinase)
• Inducer: tamoxifen
• Mutation: Insertion
• Tg(Slc6a11-cre/ERT2)1Khakh expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Slc6a11 (MGI:95630)

• Mutation details: The transgene contains the entire solute carrier family 6 (neurotransmitter transporter GABA) member 11 locus (Slc6a11 [GAT3 or Gabt4]), as well as ~48 kbp 5' (centromeric) flanking region and ~36 kbp 3' (telomeric) flanking region from BAC RP23-470B21. Using homologous recombination/BAC recombineering, a CreER cDNA sequence followed by an SV40 polyadenylation signal was inserted into exon 1 of the BAC Slc6a11 gene immediately preceding the translation initiation codon. No other loci on the BAC were altered. Unstated number of founder lines with germline transmission are generated. A founder line #1 was established and characterized. (J:249928)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Slc6a11 (mouse) Summary of all recombinase alleles driven by Slc6a11. Comparative matrix view of recombinase activities Alliance mouse Slc6a11 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:249928 Srinivasan R, et al., New Transgenic Mouse Lines for Selectively Targeting Astrocytes and Studying Calcium Signals in Astrocyte Processes In Situ and In Vivo. Neuron. 2016 Dec 21;92(6):1181-1195
• All: 1 reference(s)