Tg(Thy1-SNCA*E57K)16Ema
Transgene Detail

Summary

• Symbol: Tg(Thy1-SNCA*E57K)16Ema
• Name: transgene insertion 16, Eliezer Masliah
• MGI ID: MGI:5806788
• Synonyms: alpha-syn E57K tg, mThy1-alpha-syn E57K tg
• Transgene: Tg(Thy1-SNCA*E57K)16Ema Location: unknown
• Alliance: Tg(Thy1-SNCA*E57K)16Ema page

Transgene origin

• Strain of Origin: (C57BL/6 x DBA/2)F1

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: The human alpha-synuclein bearing the oligomer-prone E57K mutation is under the control of neuronal mouse Thy1 promoter. Three lines were generated. Lines 9 and 16 are high expressers, and line 54 is a lower expressing line. Size exclusion chromatography confirmed the formation of oligomeric alpha-synuclein. (J:236596)

Disease models

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:236596 Rockenstein E, et al., Accumulation of oligomer-prone alpha-synuclein exacerbates synaptic and neuronal degeneration in vivo. Brain. 2014 May;137(Pt 5):1496-513
• All: 3 reference(s)