Sema4a^{tm1b(EUCOMM)Wtsi}
Targeted Allele Detail

Summary

• Symbol: Sema4a^{tm1b(EUCOMM)Wtsi}
• Name: sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A; targeted mutation 1b, Wellcome Trust Sanger Institute
• MGI ID: MGI:5807134
• Synonyms: sema4a^-
• Gene: Sema4a Location: Chr3:88343266-88368489 bp, - strand Genetic Position: Chr3, 38.83 cM
• Alliance: Sema4a^{tm1b(EUCOMM)Wtsi} page
• IMPC: Sema4a gene page

Mutation origin

• Mutant Cell Line: EPD0105_3_B05
• Germline Transmission: Earliest citation of germline transmission: J:221423
• Parent Cell Line: JM8.F6 (ES Cell)
• Strain of Origin: C57BL/6N
• Project Collection: EUCOMM

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion Vector: L1L2_Bact_P
• Mutation details: Cre-mediated excision of the parental Sema4a^{tm1a(EUCOMM)Wtsi} allele resulted in the removal of the promoter-driven neomycin selection cassette and critical exon(s) leaving behind the inserted lacZ reporter sequence. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml. (J:221423)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sema4a Mutation: 39 strains or lines available

References

• Original: J:221423 Xia J, et al., Semaphorin-Plexin Signaling Controls Mitotic Spindle Orientation during Epithelial Morphogenesis and Repair. Dev Cell. 2015 May 4;33(3):299-313
• All: 3 reference(s)