Rab43^tm1.2Kmm
Targeted Allele Detail

Summary

• Symbol: Rab43^tm1.2Kmm
• Name: RAB43, member RAS oncogene family; targeted mutation 1.2, Kenneth Murphy
• MGI ID: MGI:5807220
• Synonyms: Rab43^Delta
• Gene: Rab43 Location: Chr6:87765835-87789146 bp, - strand Genetic Position: Chr6, 39.13 cM, cytoband D2
• Alliance: Rab43^tm1.2Kmm page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:237493
• Parent Cell Line: EDJ22 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: The targeting vector is designed to insert a loxP-and FRT-flanked neomycin resistance (neo) cassette upstream of exon 2. A third loxP site was inserted downstream of exon 2. Flp-mediated recombination removed the FRT-flanked neo cassette. Cre-mediated recombination removed the exon 2. (J:237493)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Rab43 Mutation: 12 strains or lines available

References

• Original: J:237493 Kretzer NM, et al., RAB43 facilitates cross-presentation of cell-associated antigens by CD8alpha+ dendritic cells. J Exp Med. 2016 Dec 12;213(13):2871-2883
• All: 2 reference(s)