Tg(Pdgfrb-cre/ERT2)6096Rha
Transgene Detail

Summary

• Symbol: Tg(Pdgfrb-cre/ERT2)6096Rha
• Name: transgene insertion 6096, Ralf H Adams
• MGI ID: MGI:5807436
• Synonyms: Pdgfrb(BAC)-CreERT2, PDGFR-beta^iCre
• Transgene: Tg(Pdgfrb-cre/ERT2)6096Rha Location: Chr5:56455226-56491644 bp Genetic Position: Chr5, Syntenic
• Alliance: Tg(Pdgfrb-cre/ERT2)6096Rha page

Transgene origin

• Strain of Origin: (C57BL/6 x 129)F1

Transgene description

• Transgene Type: Transgenic (Inducible, Recombinase)
• Inducer: tamoxifen
• Mutation: Insertion
• Tg(Pdgfrb-cre/ERT2)6096Rha expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Pdgfrb (MGI:97531)

• Mutation details: Bacterial artificial chromosome (BAC) library (CHORI) was used to obtain a BAC (#RP24-62H17TJ) containing the entire murine platelet-derived growth factor receptor, beta polypeptide (Pdgfrb) gene. This BAC was modified to insert a creER fusion gene (a cre recombinase fused to a human estrogen receptor ligand-binding domain) into the start codon of Pdgfrb to drive expression in mural cells. The other genes on the BAC (Camk2a, Slc6a7, Cdx1, Csf1r, and Hmgxb3) are still present in the construct. (J:236848)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Pdgfrb (mouse) Summary of all recombinase alleles driven by Pdgfrb. Comparative matrix view of recombinase activities Alliance mouse Pdgfrb gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:236849 Gerl K, et al., Inducible glomerular erythropoietin production in the adult kidney. Kidney Int. 2015 Dec;88(6):1345-1355
• All: 33 reference(s)