Dpp6^tm1.2Dahn
Targeted Allele Detail

Summary

• Symbol: Dpp6^tm1.2Dahn
• Name: dipeptidylpeptidase 6; targeted mutation 1.2, Dax A Hoffman
• MGI ID: MGI:5810108
• Synonyms: DPP6fl
• Gene: Dpp6 Location: Chr5:27022355-27932498 bp, + strand Genetic Position: Chr5, 12.92 cM
• Alliance: Dpp6^tm1.2Dahn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:178547
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 2. An FRT-flanked neo cassette with a 3' loxP site was inserted downstream of exon 2. FLP-mediated recombination removed the neo cassette. (J:178547)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Dpp6 Mutation: 57 strains or lines available

References

• Original: J:178547 Sun W, et al., DPP6 establishes the A-type K(+) current gradient critical for the regulation of dendritic excitability in CA1 hippocampal neurons. Neuron. 2011 Sep 22;71(6):1102-15
• All: 1 reference(s)