L3mbtl2^tm1.2Haho
Targeted Allele Detail

Summary

• Symbol: L3mbtl2^tm1.2Haho
• Name: L3MBTL2 polycomb repressive complex 1 subunit; targeted mutation 1.2, Hanno Hock
• MGI ID: MGI:5810650
• Synonyms: EX
• Gene: L3mbtl2 Location: Chr15:81548090-81572516 bp, + strand Genetic Position: Chr15, 38.19 cM
• Alliance: L3mbtl2^tm1.2Haho page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:227373
• Parent Cell Line: v6.5 (ES Cell)
• Strain of Origin: (C57BL/6 x 129S4/SvJae)F1

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: LoxP flanked exons 9-14 were removed via cre-mediated recombination. RT-PCR confirmed absence of mRNA and Western blot confirmed absence of protein. (J:227373)

Expression

In Mice Carrying this Mutation:	5 assay results
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any L3mbtl2 Mutation: 53 strains or lines available

References

• Original: J:227373 Qin J, et al., The polycomb group protein L3mbtl2 assembles an atypical PRC1-family complex that is essential in pluripotent stem cells and early development. Cell Stem Cell. 2012 Sep 7;11(3):319-32
• All: 1 reference(s)