Cdc14a^em1Tbf
Endonuclease-mediated Allele Detail

Summary

• Symbol: Cdc14a^em1Tbf
• Name: CDC14 cell division cycle 14A; endonuclease-mediated mutation 1, Thomas B Friedman
• MGI ID: MGI:5810960
• Synonyms: C278S-CDC14A
• Gene: Cdc14a Location: Chr3:116066202-116222390 bp, - strand Genetic Position: Chr3, 50.24 cM
• Alliance: Cdc14a^em1Tbf page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Not Applicable)
• Mutation: Single point mutation
• Mutation details: CRISPR/Cas-9 technology was used to generate a single point mutation (c.832T>A) which results in a serine to cysteine substitution at codon-278 (p.C278S) that ablates phosphatase catalytic activity while maintaining overall protein tertiary structure. (J:257652)

Disease models

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cdc14a Mutation: 35 strains or lines available

References

• Original: J:257652 Imtiaz A, et al., CDC14A phosphatase is essential for hearing and male fertility in mouse and human. Hum Mol Genet. 2018 Mar 1;27(5):780-798
• All: 1 reference(s)