Cbfa2t2^em1Dare
Endonuclease-mediated Allele Detail

Summary

• Symbol: Cbfa2t2^em1Dare
• Name: CBFA2/RUNX1 translocation partner 2; endonuclease-mediated mutation 1, Danny Reinberg
• MGI ID: MGI:5811012
• Synonyms: Cbfa2t2^-
• Gene: Cbfa2t2 Location: Chr2:154278401-154381276 bp, + strand Genetic Position: Chr2, 76.62 cM, cytoband C3.2
• Alliance: Cbfa2t2^em1Dare page

Mutation origin

• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/Cas9 system was used to target exon 6 of Cbfa2t2 gene to delete 7-bp fragment to cause a frame-shift within the coding exon. (J:233954)

Expression

In Mice Carrying this Mutation:	29 assay results
In Structures Affected by this Mutation:	4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cbfa2t2 Mutation: 211 strains or lines available

References

• Original: J:233954 Tu S, et al., Co-repressor CBFA2T2 regulates pluripotency and germline development. Nature. 2016 Jun 16;534(7607):387-90
• All: 1 reference(s)