Grin2a^tm1.1Jpleo
Targeted Allele Detail

Summary

• Symbol: Grin2a^tm1.1Jpleo
• Name: glutamate receptor, ionotropic, NMDA2A (epsilon 1); targeted mutation 1.1, John P Leonard
• MGI ID: MGI:5811328
• Synonyms: deltaPKC, Grin2adeltaPKC
• Gene: Grin2a Location: Chr16:9385762-9813424 bp, - strand Genetic Position: Chr16, 5.28 cM
• Alliance: Grin2a^tm1.1Jpleo page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:235504
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Not Applicable)
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: A targeting vector containing mutations that result in amino acid substitutions S1991A, Y1292F, S1312A and Y1472F, and a loxP site flanked NEO cassette was used to disrupt exon 12. Cre-mediated recombination removed the floxed neo cassette. (J:235504)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Grin2a Mutation: 66 strains or lines available

References

• Original: J:235504 Balu D, et al., Behavioral and physiological characterization of PKC-dependent phosphorylation in the Grin2aPKC mouse. Brain Res. 2016 Sep 1;1646:315-26
• All: 1 reference(s)