Hint2^tm1.1Geno
Targeted Allele Detail

Summary

• Symbol: Hint2^tm1.1Geno
• Name: histidine triad nucleotide binding protein 2; targeted mutation 1.1, Genoway
• MGI ID: MGI:5812015
• Gene: Hint2 Location: Chr4:43654227-43656445 bp, - strand Genetic Position: Chr4, 23.05 cM, cytoband B1
• Alliance: Hint2^tm1.1Geno page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:237329
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of exon 1 and a FRT-neomycin-FRT-loxP selection cassette was inserted downstream of exon 5. Exons 1-5 were deleted via cre-mediated recombination. Western blot confirmed absence of protein in liver and pancreas. (J:237329)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 3 strains available Cell Lines: 0 lines available
• Carrying any Hint2 Mutation: 25 strains or lines available

References

• Original: J:237329 Martin J, et al., Disruption of the histidine triad nucleotide-binding hint2 gene in mice affects glycemic control and mitochondrial function. Hepatology. 2013 May;57(5):2037-48
• All: 4 reference(s)