Smcr8^{tm1.1(KOMP)Vlcg}
Targeted Allele Detail

Summary

• Symbol: Smcr8^{tm1.1(KOMP)Vlcg}
• Name: Smith-Magenis syndrome chromosome region, candidate 8 homolog (human); targeted mutation 1.1, Velocigene
• MGI ID: MGI:5812680
• Gene: Smcr8 Location: Chr11:60668351-60679113 bp, + strand Genetic Position: Chr11, 37.83 cM
• Alliance: Smcr8^{tm1.1(KOMP)Vlcg} page
• IMPC: Smcr8 gene page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:236977
• Parent Cell Line: VGB6 (ES Cell)
• Strain of Origin: C57BL/6NTac
• Project Collection: KOMP-Regeneron

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The insertion of Velocigene cassette ZEN-Ub1 created a deletion of size 2434 bp between positions 60591533-60593966 of Chromosome 11 (Genome Build37). The gene locus is partially replaced by a cassette containing lacZ-polyA followed by a loxP-flanked hUbCpro-neo-polyA sequence. Cre-mediated recombination removed the neomycin selection cassette. (J:236977)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Smcr8 Mutation: 40 strains or lines available

References

• Original: J:136110 Velocigene, Alleles produced for the KOMP project by Velocigene (Regeneron Pharmaceuticals). MGI Direct Data Submission. 2008
• All: 4 reference(s)