Naf1^em1Arman
Endonuclease-mediated Allele Detail

Summary

• Symbol: Naf1^em1Arman
• Name: nuclear assembly factor 1 ribonucleoprotein; endonuclease-mediated mutation 1, Mary Armanios
• MGI ID: MGI:5816378
• Gene: Naf1 Location: Chr8:67312869-67343216 bp, + strand Genetic Position: Chr8, 33.18 cM
• Alliance: Naf1^em1Arman page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Not Specified)
• Mutation: Intragenic deletion
• Mutation details: A single guide RNA designed to target exon 1 of the gene and the cas9 nuclease were used to introduce a 322 bp deletion in exon 1. (J:237554)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Naf1 Mutation: 35 strains or lines available

References

• Original: J:237554 Stanley SE, et al., Loss-of-function mutations in the RNA biogenesis factor NAF1 predispose to pulmonary fibrosis-emphysema. Sci Transl Med. 2016 Aug 10;8(351):351ra107
• All: 1 reference(s)