Zfp36l3^tm1Pjb
Targeted Allele Detail

Summary

• Symbol: Zfp36l3^tm1Pjb
• Name: zinc finger protein 36, C3H type-like 3; targeted mutation 1, Perry J Blackshear
• MGI ID: MGI:5816709
• Gene: Zfp36l3 Location: ChrX:52776015-52778361 bp, - strand Genetic Position: ChrX, 30.06 cM
• Alliance: Zfp36l3^tm1Pjb page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:230794
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP-flanked neomycin selection cassette replaced the coding region of the gene. Cre-mediated recombination removed the neomycin cassette. Northern blotting of placenta total cellular RNA confirmed absence of mRNA and immunoblotting and immunohistochemistry of the placenta confirmed absence of protein. (J:230794)

Expression

In Mice Carrying this Mutation:

16 assay results 3 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Zfp36l3 Mutation: 4 strains or lines available

References

• Original: J:230794 Stumpo DJ, et al., Deficiency of the placenta- and yolk sac-specific tristetraprolin family member ZFP36L3 identifies likely mRNA targets and an unexpected link to placental iron metabolism. Development. 2016 Apr 15;143(8):1424-33
• All: 1 reference(s)