Ccp110^tm1.2Asw
Targeted Allele Detail

Summary

• Symbol: Ccp110^tm1.2Asw
• Name: centriolar coiled coil protein 110; targeted mutation 1.2, Anand Swaroop
• MGI ID: MGI:5816715
• Synonyms: Cp110^-
• Gene: Ccp110 Location: Chr7:118311775-118336247 bp, + strand Genetic Position: Chr7, 63.58 cM
• Alliance: Ccp110^tm1.2Asw page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:232855
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Exon 5 was flanked by loxP sites. An FRT-flanked neomycin selection cassette was removed by breeding heterozygous floxed animals with actin-Flp recombinase mice, and the loxP-flanked exon 5 sequences were removed by breeding with zona pellucida promoter-driven Cre mice which express Cre in developing oocytes. Immunoblot analysis using anti-CP110 antibody on protein extracts confirmed the absence of protein expression in E14.5 homozygous mutant embryos. (J:232855)

Expression

In Structures Affected by this Mutation:

22 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ccp110 Mutation: 32 strains or lines available

Notes

Phenotypic Similarity to Human Syndrome: Short Rib-Polydactyly Syndrome (J:232855).

References

• Original: J:232855 Yadav SP, et al., Centrosomal protein CP110 controls maturation of the mother centriole during cilia biogenesis. Development. 2016 May 1;143(9):1491-501
• All: 1 reference(s)