Rpl13a^tm1.1Jesc
Targeted Allele Detail

Summary

• Symbol: Rpl13a^tm1.1Jesc
• Name: ribosomal protein L13A; targeted mutation 1.1, Jean Schaffer
• MGI ID: MGI:5816858
• Synonyms: Rpl13a-snoless
• Gene: Rpl13a Location: Chr7:44774987-44778169 bp, - strand Genetic Position: Chr7, 29.14 cM
• Alliance: Rpl13a^tm1.1Jesc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:237822
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S5/SvEvBrd

Mutation description

• Allele Type: Targeted (Not Applicable)
• Mutation: Intragenic deletion
• Mutation details: A targeting construct incorporating exons 1-8 is used to place a loxP-flanked neomycin cassette in intron 1, and remove U32a, U33, U34, and U35a small nucleolar RNAs (snoRNAs) from introns 2, 4, 5, and 6, respectively. Cre-mediated recombination removed the floxed neo cassette. Rpl13a mRNA and protein levels are indistinguishable from wild-type controls. (J:237822)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Rpl13a Mutation: 40 strains or lines available

References

• Original: J:237822 Lee J, et al., Rpl13a small nucleolar RNAs regulate systemic glucose metabolism. J Clin Invest. 2016 Dec 01;126(12):4616-4625
• All: 3 reference(s)