Il23rtm1Kuv
Targeted Allele Detail
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Symbol: |
Il23rtm1Kuv |
Name: |
interleukin 23 receptor; targeted mutation 1, Universitat Kiel |
MGI ID: |
MGI:5816976 |
Synonyms: |
Il23rflox, Il23rtm1.1Geno |
Gene: |
Il23r Location: Chr6:67399916-67468839 bp, - strand Genetic Position: Chr6, 30.85 cM
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Alliance: |
Il23rtm1Kuv page
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Germline Transmission: |
Earliest citation of germline transmission:
J:237237
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Parent Cell Line: |
Not Specified (ES Cell)
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Strain of Origin: |
129/Sv
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Allele Type: |
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Targeted (Conditional ready) |
Mutation: |
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Insertion
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Mutation details: The proximal loxP site was inserted together with a neomycin selection cassette flanked by FRT sites within intron 3 of the Il23r gene, the distal loxP site was introduced within intron 4. The resultant mouse line was bred to a FLP deleter-line, which ubiquitously expresses Flp-recombinase to excise the neomycin selection cassette.
(J:237237)
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Original: |
J:237237 Yoon J, et al., IL-23 induced in keratinocytes by endogenous TLR4 ligands polarizes dendritic cells to drive IL-22 responses to skin immunization. J Exp Med. 2016 Sep 19;213(10):2147-66 |
All: |
4 reference(s) |
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