Twbq2^C57BL/6J
QTL Variant Detail

Summary

• QTL variant: Twbq2^C57BL/6J
• Name: Total wake bout mean duration QTL 2; C57BL/6J
• MGI ID: MGI:5817117
• QTL: Twbq2 Location: unknown Genetic Position: Chr6, Syntenic

Variant origin

• Strain of Specimen: C57BL/6J

Variant description

• Allele Type: QTL
• Inheritance: Not Specified

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:148505

The authors measured 20 sleep-wake traits that are most commonly used in the literature to describe sleep in rodent models. Linkage analysis was conducted with a set of 2,310 informative SNPs across the 19 autosomes from 269 [C57BL/6J x (BALB/cByJ x C57BL/6J) F1] N2 male mice for which both complete and high quality genotype and sleep-wake phenotype data were obtained. The 48-hr sleep recording period was partitioned into two 24-hr periods and further into a light and dark phase yielding four recording time domains per animal during which each sleep trait was computed. Full EEG and EMG recordings over 48 hrs were collected from each N2 animal and sleep-wake parameters, defined by visually characterizing each 10 second epoch as wake, NREM, or REM sleep, and performing EEG spectral analysis, allowed for the measurement of 72 parameters defining sleep structure and continuity as well as EEG waveform activity. A total of 52 QTL corresponding to the 20 most common sleep-wake traits reached genome-wide significance:

QTL Slaq1 (Sleep arousal QTL 1) maps to Chromosome 1 from 7.55 - 192.48 Mb (0.00 - 83.81 cM) with a peak LOD score of 4.23 at 172.89 Mb (62.23 cM).

QTL Slaq2 (Sleep arousal QTL 2) maps to Chromosome 1 from 172.89 - 193.61 Mb (62.23 - 87.42 cM) with a peak LOD score of 2.49 at 189.31 Mb (76.96 cM).

QTL Slaq3 (Sleep arousal QTL 3) maps to Chromosome 13 from 4.69 - 38.70 Mb (0.00 - 12.80 cM) with a peak LOD score of 2.54 at 4.69 Mb (0.00 cM).

QTL Sssq1 (Sleep state shift QTL 1) maps to Chromosome 1 from 7.55 - 172.89 Mb (0.00 - 62.23 cM) with a peak LOD score of 3.08 at 133.90 Mb (42.40 cM).

QTL Sssq2 (Sleep state shift QTL 2) maps to Chromosome 6 from 125.33 - 147.81 Mb (63.10 - 85.88 cM) with a peak LOD score of 3.11 at 135.77 Mb (70.00 cM).

QTL Remstpq1 (REM sleep time percentage QTL 1) maps to Chromosome 5 from 27.45 - 130.39 Mb (11.37 - 73.28 cM) with a peak LOD score of 4.23 at 65.32 Mb (45.29 cM).

QTL Remstpq2 (REM sleep time percentage QTL 2) maps to Chromosome 13 from 4.69 - 107.66 Mb (0.00 - 47.60 cM) with a peak LOD score of 6.47 at 68.69 Mb (22.66 cM).

QTL Remstpq3 (REM sleep time percentage QTL 3) maps to Chromosome 15 from 13.00 - 100.81 Mb (0.00 - 50.07 cM) with a peak LOD score of 4.04 at 82.41 Mb (26.30 cM).

QTL Remstpq4 (REM sleep time percentage QTL 4) maps to Chromosome 17 from 4.30 - 94.53 Mb (0.00 - 68.38 cM) with a peak LOD score of 4.26 at 24.85 Mb (3.94 cM).

QTL Nremsbq1 (NREM sleep bout mean duration QTL 1) maps to Chromosome 1 from 7.55 - 172.89 Mb (0.00 - 62.23 cM) with a peak LOD score of 3.44 at 115.68 Mb (39.12 cM).

QTL Nremsbq2 (NREM sleep bout mean duration QTL 2) maps to Chromosome 1 from 158.09 - 195.81 Mb (52.42 - 89.72 cM) with a peak LOD score of 3.18 at 189.31 Mb (76.96 cM).

QTL Nremsbq3 (NREM sleep bout mean duration QTL 3) maps to Chromosome 12 from 37.54 - 118.44 Mb (13.13 - 63.53 cM) with a peak LOD score of 3.12 at 71.05 Mb (27.58 cM).

QTL Remsbq1 (REM sleep bout mean duration QTL 1) maps to Chromosome 5 from 4.09 - 150.24 Mb (0.00 - 105.49 cM) with a peak LOD score of 6.34 at 70.39 Mb (49.32 cM).

QTL Remsbq2 (REM sleep bout mean duration QTL 2) maps to Chromosome 13 from 18.73 - 94.46 Mb (2.63 - 36.38 cM) with a peak LOD score of 3.30 at 60.14 Mb (20.03 cM).

QTL Tsbq1 (Total sleep bout mean duration QTL 1) maps to Chromosome 1 from 7.55 - 172.89 Mb (0.00 - 62.23 cM) with a peak LOD score of 3.45 at 115.68 Mb (39.12 cM).

QTL Tsbq2 (Total sleep bout mean duration QTL 2) maps to Chromosome 1 from 158.09 - 195.81 Mb (52.42 - 89.72 cM) with a peak LOD score of 3.25 at 187.59 Mb (74.20 cM).

QTL Tsbq3 (Total sleep bout mean duration QTL 3) maps to Chromosome 12 from 37.54 - 118.44 Mb (13.13 - 63.53 cM) with a peak LOD score of 3.11 at 71.05 Mb (27.58 cM).

QTL Tsbq4 (Total sleep bout mean duration QTL 4) maps to Chromosome 17 from 4.30 - 60.86 Mb (0.00 - 22.45 cM) with a peak LOD score of 2.60 at 44.79 Mb (13.12 cM).

QTL Twbq1 (Total wake bout mean duration QTL 1) maps to Chromosome 1 from 144.78 - 195.81 Mb (48.32 - 89.72 cM) with a peak LOD score of 3.99 at 172.89 Mb (62.23 cM).

QTL Twbq2 (Total wake bout mean duration QTL 2) maps to Chromosome 6 from 100.21 - 147.81 Mb (54.25 - 85.88 cM) with a peak LOD score of 3.67 at 135.77 Mb (70.00 cM).

QTL Twbq3 (Total wake bout mean duration QTL 3) maps to Chromosome 7 from 3.64 - 35.48 Mb (0.00 - 22.34 cM) with a peak LOD score of 3.11 at 7.88 Mb (0.98 cM).

QTL Twbq3 (Total wake bout mean duration QTL 3) maps to Chromosome 7 from 3.64 - 35.48 Mb (0.00 - 22.34 cM) with a peak LOD score of 3.11 at 7.88 Mb (0.98 cM).

QTL Iremsq1 (Inter-REM sleep interval QTL 1) maps to Chromosome 7 from 97.98 - 132.71 Mb (57.60 - 81.93 cM) with a peak LOD score of 4.01 at 102.97 Mb (59.90 cM).

QTL Iremsq2 (Inter-REM sleep interval QTL 2) maps to Chromosome 13 from 23.30 - 107.66 Mb (5.58 - 47.60 cM) with a peak LOD score of 3.93 at 72.82 Mb (25.94 cM).

QTL Nremslq1 (NREM sleep latency QTL 1) maps to Chromosome 1 from 133.90 - 195.81 Mb (42.40 - 89.72 cM) with a peak LOD score of 4.53 at 187.59 Mb (74.20 cM).

QTL Nremslq2 (NREM sleep latency QTL 2) maps to Chromosome 1 from 158.09 - 195.81 Mb (52.42 - 89.72 cM) with a peak LOD score of 2.80 at 187.59 Mb (74.20 cM).

QTL Nremslq3 (NREM sleep latency QTL 3) maps to Chromosome 3 from 123.44 - 159.44 Mb (56.89 - 85.24 cM) with a peak LOD score of 3.24 at 146.07 Mb (71.06 cM).

QTL Nremslq4 (NREM sleep latency QTL 4) maps to Chromosome 9 from 13.21 - 105.03 Mb (0.00 - 57.37 cM) with a peak LOD score of 3.06 at 46.53 Mb (15.16 cM).

QTL Remslq1 (REM sleep latency QTL 1) maps to Chromosome 1 from 133.90 - 192.48 Mb (42.40 - 83.81 cM) with a peak LOD score of 2.94 at 172.89 Mb (62.23 cM).

QTL Remslq2 (REM sleep latency QTL 2) maps to Chromosome 13 from 4.69 - 47.46 Mb (0.00 - 18.06 cM) with a peak LOD score of 2.83 at 14.55 Mb (1.64 cM).

QTL Remslq3 (REM sleep latency QTL 3) maps to Chromosome 14 from 104.43 - 123.65 Mb (54.84 - 74.95 cM) with a peak LOD score of 3.06 at 121.78 Mb (72.98 cM).

QTL Nremsqq1 (NREM sleep quantity QTL 1) maps to Chromosome 1 from 7.55 - 173.96 Mb (0.00 - 62.69 cM) with a peak LOD score of 3.49 at 133.90 Mb (42.40 cM).

QTL Nremsqq2 (NREM sleep quantity QTL 2) maps to Chromosome 6 from 125.33 - 147.81 Mb (63.10 - 85.88 cM) with a peak LOD score of 3.08 at 135.77 Mb (70.00 cM).

QTL Remsqq1 (REM sleep quantity QTL 1) maps to Chromosome 7 from 29.49 - 127.18 Mb (17.15 - 75.66 cM) with a peak LOD score of 4.29 at 50.22 Mb (31.77 cM).

QTL Remsqq2 (REM sleep quantity QTL 2) maps to Chromosome 17 from 4.30 - 94.53 Mb (0.00 - 68.38 cM) with a peak LOD score of 4.87 at 65.20 Mb (28.59 cM).

QTL Wbqq1 (Wake bout quantity QTL 1) maps to Chromosome 1 from 164.32 - 189.31 Mb (53.40 - 76.96 cM) with a peak LOD score of 3.29 at 176.45 Mb (63.68 cM).

QTL Wbqq2 (Wake bout quantity QTL 2) maps to Chromosome 7 from 3.64 - 64.55 Mb (0.00 - 38.56 cM) with a peak LOD score of 4.06 at 7.88 Mb (0.98 cM).

QTL Nremstq1 (Total NREM sleep time QTL 1) maps to Chromosome 7 from 98.90 - 139.71 Mb (58.58 - 91.21 cM) with a peak LOD score of 4.44 at 114.92 Mb (65.14 cM).

QTL Nremstq2 (Total NREM sleep time QTL 2) maps to Chromosome 13 from 4.69 - 63.34 Mb (0.00 - 20.69 cM) with a peak LOD score of 3.59 at 16.72 Mb (1.97 cM).

QTL Nremstq3 (Total NREM sleep time QTL 3) maps to Chromosome 17 from 26.65 - 94.53 Mb (5.58 - 68.38 cM) with a peak LOD score of 5.95 at 65.62 Mb (30.23 cM).

QTL Dpnrems1 (Relative delta power in NREM sleep 1) maps to Chromosome 1 from 172.89 - 189.31 Mb (62.23 - 76.96 cM) with a peak LOD score of 3.10 at 187.59 Mb (74.20 cM).

QTL Dpnrems1 (Relative delta power in NREM sleep 1) maps to Chromosome 1 from 172.89 - 189.31 Mb (62.23 - 76.96 cM) with a peak LOD score of 3.10 at 187.59 Mb (74.20 cM).

QTL Dpnrems2 (Relative delta power in NREM sleep 2) maps to Chromosome 3 from 3.77 - 68.66 Mb (0.00 - 29.58 cM) with a peak LOD score of 2.74 at 30.69 Mb (12.18 cM).

QTL Oremsq1 (Onset REM sleep QTL 1) maps to Chromosome 1 from 7.55 - 176.45 Mb (0.00 - 63.68 cM) with a peak LOD score of 4.44 at 109.04 Mb (38.47 cM).

QTL Oremsq2 (Onset REM sleep QTL 2) maps to Chromosome 1 from 158.09 - 194.42 Mb (52.42 - 88.73 cM) with a peak LOD score of 3.48 at 188.87 Mb (74.58 cM).

QTL Remslp6 (Rapid eye movement sleep 6) maps to Chromosome 5 from 4.09 - 137.03 Mb (0.00 - 84.49 cM) with a peak LOD score of 4.22 at 73.50 Mb (51.94 cM).

QTL Tremstq1 (Total REM sleep time QTL 1) maps to Chromosome 7 from 29.05 - 118.60 Mb (16.82 - 69.42 cM) with a peak LOD score of 3.61 at 67.41 Mb (40.20 cM).

QTL Tremstq2 (Total REM sleep time QTL 2) maps to Chromosome 13 from 4.69 - 105.55 Mb (0.00 - 45.31 cM) with a peak LOD score of 6.30 at 68.69 Mb (22.66 cM).

QTL Tremstq3 (Total REM sleep time QTL 3) maps to Chromosome 17 from 4.30 - 94.53 Mb (0.00 - 68.38 cM) with a peak LOD score of 3.02 at 65.20 Mb (28.59 cM).

QTL Tprems1 (Relative theta 1 power in REM sleep 1) maps to Chromosome 1 from 67.81 - 187.59 Mb (27.96 - 27.96 cM) with a peak LOD score of 2.79 at 176.45 Mb (63.68 cM).

QTL Tprems2 (Relative theta 1 power in REM sleep 2) maps to Chromosome 16 from 6.92 - 86.71 Mb (0.33 - 45.66 cM) with a peak LOD score of 3.04 at 51.54 Mb (23.66 cM).

QTL Wtq1 (Total wake time QTL 1) maps to Chromosome 7 from 98.90 - 139.71 Mb (58.58 - 91.21 cM) with a peak LOD score of 4.81 at 114.07 Mb (62.85 cM).

QTL Wtq2 (Total wake time QTL 2) maps to Chromosome 13 from 4.69 - 83.45 Mb (0.00 - 31.20 cM) with a peak LOD score of 5.14 at 16.72 Mb (1.97 cM).

QTL Wtq3 (Total wake time QTL 3) maps to Chromosome 17 from 26.65 - 94.53 Mb (5.58 - 68.38 cM) with a peak LOD score of 7.56 at 65.62 Mb (30.23 cM).

References

• Original: J:148505 Winrow CJ, et al., Uncovering the genetic landscape for multiple sleep-wake traits. PLoS One. 2009;4(4):e5161
• All: 1 reference(s)