Mir301^tm1Yoli
Targeted Allele Detail

Summary

• Symbol: Mir301^tm1Yoli
• Name: microRNA 301; targeted mutation 1, Yong Li
• MGI ID: MGI:5817372
• Synonyms: miR-301a^-
• Gene: Mir301 Location: Chr11:87003830-87003915 bp, + strand Genetic Position: Chr11, 51.92 cM
• Alliance: Mir301^tm1Yoli page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:101977
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A targeting vector was designed to replace the entire coding region of the microRNA 301 (Mir301) gene with a FRT-flanked neomycin resistance (neo) cassette. (J:237900)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Mir301^tm1Yoli

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Mir301 Mutation: 4 strains or lines available

References

• Original: J:237900 Ma X, et al., Modulation of tumorigenesis by the pro-inflammatory microRNA miR-301a in mouse models of lung cancer and colorectal cancer. Cell Discov. 2015;1:15005
• All: 2 reference(s)