Tyr^em4Ove
Endonuclease-mediated Allele Detail

Summary

• Symbol: Tyr^em4Ove
• Name: tyrosinase; endonuclease-mediated mutation 4, Paul Overbeek
• MGI ID: MGI:5817601
• Synonyms: OVE modTP-4, tyro promo (-50/-500)-1D
• Gene: Tyr Location: Chr7:87073979-87142637 bp, - strand Genetic Position: Chr7, 49.01 cM
• Alliance: Tyr^em4Ove page

Mutation origin

• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Endonuclease-mediated (Hypomorph)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/Cas9 technology was used to generate a 243-bp deletion in the promoter of the tyrosinase gene, extending from position -323 through -80 with respect to the translation-initiating ATG codon. (J:94077)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Tyr Mutation: 379 strains or lines available

References

• Original: J:94077 Mutant Mouse Regional Resource Centers, Information obtained from the Mutant Mouse Regional Resource Centers (MMRRC). Unpublished. 2004-2015
• All: 1 reference(s)