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Cgref1em1(IMPC)J
Endonuclease-mediated Allele Detail
Summary
Symbol: Cgref1em1(IMPC)J
Name: cell growth regulator with EF hand domain 1; endonuclease-mediated mutation 1, Jackson
MGI ID: MGI:5817761
Synonyms: Cgref1em1J
Gene: Cgref1  Location: Chr5:31090487-31102771 bp, - strand  Genetic Position: Chr5, 16.9 cM
Alliance: Cgref1em1(IMPC)J page
IMPC: Cgref1 gene page
Mutation
origin
Strain of Origin:  C57BL/6NJ
Project Collection: IMPC
Mutation
description
Allele Type:    Endonuclease-mediated (Null/knockout)
Mutation:    Intragenic deletion
 
Mutation detailsThis allele from project Cgref1-8199J-F4208 was generated at The Jackson Laboratory by injecting Cas9 RNA and 4 guide sequences GCCCAGTGTGAAGCATCAGA, TTAGAATAAGACCTGACACT, GGAGGACTATGAATACCCAT and GAATGGTTCCACATGCAAGG, which resulted in a 489 bp deletion beginning at Chromosome 5 negative strand position 30,936,119 bp, GTATTCATAGTCCTCCCTGA, and ending after AGAATAAGACCTGACACTGG at 30,935,631 bp (GRCm38/mm10). This mutation deletes exon 2 and 386 bp of flanking intronic sequence including the splice acceptor and donor, and is predicted to cause a change of amino acid sequence after residue 39 and early truncation 31 amino acids later. (J:188991)
Inheritance:    Not Specified
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 2 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Cgref1 Mutation:  15 strains or lines available
References
Original:  J:188991 The Jackson Laboratory, Alleles produced for the KOMP project by The Jackson Laboratory. MGI Direct Data Submission. 2012;
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory