Begain^tm1.1Tayk
Targeted Allele Detail

Summary

• Symbol: Begain^tm1.1Tayk
• Name: brain-enriched guanylate kinase-associated; targeted mutation 1.1, Tayo Katano
• MGI ID: MGI:5818151
• Gene: Begain Location: Chr12:108998113-109034143 bp, - strand Genetic Position: Chr12, 59.98 cM
• Alliance: Begain^tm1.1Tayk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:237768
• Parent Cell Line: RENKA (ES Cell)
• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted into intron 3 and an FRT site flanked neomycin resistance gene cassette and a second loxP site into intron 5. Exons 4 and 5 (and the neo cassette) were deleted through cre-mediated recombination, creating a knock-out allele. RT-PCR confirmed absence of transcription from this allele in spinal dorsal horns and dorsal root ganglia. (J:237768)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Begain Mutation: 24 strains or lines available

References

• Original: J:237768 Katano T, et al., Involvement of Brain-Enriched Guanylate Kinase-Associated Protein (BEGAIN) in Chronic Pain after Peripheral Nerve Injury. eNeuro. 2016 Sep-Oct;3(5):ENEURO.0110-16.2016
• All: 2 reference(s)