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Zdhhc3tm1.2Lusc
Targeted Allele Detail
Summary
Symbol: Zdhhc3tm1.2Lusc
Name: zinc finger, DHHC domain containing 3; targeted mutation 1.2, Bernhard Luscher
MGI ID: MGI:5818156
Synonyms: GODZ KO
Gene: Zdhhc3  Location: Chr9:122895224-122942269 bp, - strand  Genetic Position: Chr9, 73.66 cM, cytoband F4
Alliance: Zdhhc3tm1.2Lusc page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:237763
Parent Cell Line:  BK4 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA loxP site was inserted into intron 2 and a loxP site flanked neomycin resistance gene cassette into intron 4. The neo cassette was removed through cre-mediated recombination. Exons 3 and 4 were removed through subsequent cre-mediated recombination, resulting in a knock-out allele. The two exons encode the DHHC-CRD domain. RT-PCR, Western blots and immunohistochemistry confirmed absence of transcription and translation from this allele. (J:237763)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Zdhhc3 Mutation:  39 strains or lines available
References
Original:  J:237763 Kilpatrick CL, et al., Dissociation of Golgi-associated DHHC-type Zinc Finger Protein (GODZ)- and Sertoli Cell Gene with a Zinc Finger Domain-beta (SERZ-beta)-mediated Palmitoylation by Loss of Function Analyses in Knock-out Mice. J Biol Chem. 2016 Dec 30;291(53):27371-27386
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory