Hnrnpa1^tm1.1Cyf
Targeted Allele Detail

Summary

• Symbol: Hnrnpa1^tm1.1Cyf
• Name: heterogeneous nuclear ribonucleoprotein A1; targeted mutation 1.1, Yung-Fu Chang
• MGI ID: MGI:5818661
• Gene: Hnrnpa1 Location: Chr15:103148859-103155119 bp, + strand Genetic Position: Chr15, 58.58 cM, cytoband F3
• Alliance: Hnrnpa1^tm1.1Cyf page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:238260
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of exon 2. An FRT-flanked neomycin resistance cassette with a 3' loxP site was inserted downstream of exon 7. Cre-mediated recombination removed the selection cassette and exons 2 through 7. Western blot analysis confirmed the absence of protein expression in the heart. (J:238260)

Expression

In Mice Carrying this Mutation:	117 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hnrnpa1 Mutation: 20 strains or lines available

References

• Original: J:238260 Liu TY, et al., Muscle developmental defects in heterogeneous nuclear Ribonucleoprotein A1 knockout mice. Open Biol. 2017 Jan;7(1)
• All: 1 reference(s)