Raph1^tm1.1Fbg
Targeted Allele Detail

Summary

• Symbol: Raph1^tm1.1Fbg
• Name: Ras association (RalGDS/AF-6) and pleckstrin homology domains 1; targeted mutation 1.1, Frank B Gertler
• MGI ID: MGI:5818705
• Synonyms: Lpd^flox
• Gene: Raph1 Location: Chr1:60521451-60606263 bp, - strand Genetic Position: Chr1, 30.48 cM
• Alliance: Raph1^tm1.1Fbg page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:101977
• Parent Cell Line: v6.5 (ES Cell)
• Strain of Origin: (C57BL/6 x 129S4/SvJae)F1

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: The targeting vector is designed to insert loxP sites flanking the entire coding region. A FRT-flanked neomycin resistance (neo) cassette was inserted upstream of the 3' loxP site. Flp-mediated recombination removed the FRT-flanked neo cassette. (J:238262)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Raph1 Mutation: 60 strains or lines available

References

• Original: J:238262 Miller CL, et al., Lamellipodin-Deficient Mice: A Model of Rectal Carcinoma. PLoS One. 2016;11(4):e0152940
• All: 2 reference(s)