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Raph1tm1.2Fbg
Targeted Allele Detail
Summary
Symbol: Raph1tm1.2Fbg
Name: Ras association (RalGDS/AF-6) and pleckstrin homology domains 1; targeted mutation 1.2, Frank B Gertler
MGI ID: MGI:5818712
Synonyms: Lpd-, Raph1tm1Fbg
Gene: Raph1  Location: Chr1:60521451-60606263 bp, - strand  Genetic Position: Chr1, 30.48 cM
Alliance: Raph1tm1.2Fbg page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:238262
Parent Cell Line:  v6.5 (ES Cell)
Strain of Origin:  (C57BL/6 x 129S4/SvJae)F1
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
 
Mutation detailsThe targeting vector is designed to insert loxP sites flanking the entire coding region. A FRT-flanked neomycin resistance (neo) cassette was inserted upstream of the 3' loxP site. Cre-mediated recombination removed the coding region. (J:238262)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 4 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Raph1 Mutation:  60 strains or lines available
Notes
Phenotypic Similarity to Human Syndrome: Rectal Carcinoma J: 238262.
References
Original:  J:238262 Miller CL, et al., Lamellipodin-Deficient Mice: A Model of Rectal Carcinoma. PLoS One. 2016;11(4):e0152940
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
12/10/2024
MGI 6.24
The Jackson Laboratory