Alpl^tm2.1Jlm
Targeted Allele Detail

Summary

• Symbol: Alpl^tm2.1Jlm
• Name: alkaline phosphatase, liver/bone/kidney; targeted mutation 2.1, Jose Luis Millan
• MGI ID: MGI:5818891
• Synonyms: Alpl^A116T
• Gene: Alpl Location: Chr4:137469044-137523695 bp, - strand Genetic Position: Chr4, 70.02 cM
• Alliance: Alpl^tm2.1Jlm page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:237759
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Dominant negative, Humanized sequence)
• Mutation: Single point mutation
• Mutation details: A c.346G>A base change, corresponding to an A116T substitution, was introduced into exon 5. A loxP flanked neomycin resistance cassette was removed via cre-mediated recombination. (J:237759)

Disease models

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Alpl Mutation: 352 strains or lines available

References

• Original: J:237759 Foster BL, et al., Periodontal Defects in the A116T Knock-in Murine Model of Odontohypophosphatasia. J Dent Res. 2015 May;94(5):706-14
• All: 1 reference(s)