Htr2c^{tm1.1(cre)Heis}
Targeted Allele Detail

Summary

• Symbol: Htr2c^{tm1.1(cre)Heis}
• Name: 5-hydroxytryptamine (serotonin) receptor 2C; targeted mutation 1.1, Lora Heisler
• MGI ID: MGI:5819075
• Synonyms: 5-HT2CR^CRE
• Gene: Htr2c Location: ChrX:145745509-145980273 bp, + strand Genetic Position: ChrX, 68.46 cM, cytoband D-F4
• Alliance: Htr2c^{tm1.1(cre)Heis} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:238329
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Recombinase)
• Mutation: Insertion
• Htr2c^{tm1.1(cre)Heis} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Htr2c (MGI:96281)

• Mutation details: The targeting construct was generated by insertion of a FRT-NEO-FRT-IRES-CRE cassette between the stop codon and the polyA site of the gene. Homologous recomination in ES cells generated correctly targetted mice. Crossing resulting mice with FlpO deleter mice removed the selection cassette. (J:238329)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Htr2c (mouse) Summary of all recombinase alleles driven by Htr2c. Comparative matrix view of recombinase activities Alliance mouse Htr2c gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Htr2c Mutation: 13 strains or lines available

References

• Original: J:238329 Burke LK, et al., Sex difference in physical activity, energy expenditure and obesity driven by a subpopulation of hypothalamic POMC neurons. Mol Metab. 2016 Mar;5(3):245-52
• All: 8 reference(s)