Tardbp^{tm1(TARDBP*G348C/Venus)Okn}
Targeted Allele Detail

Summary

• Symbol: Tardbp^{tm1(TARDBP*G348C/Venus)Okn}
• Name: TAR DNA binding protein; targeted mutation 1, Hideyuki Okano
• MGI ID: MGI:5819107
• Gene: Tardbp Location: Chr4:148696839-148711476 bp, - strand Genetic Position: Chr4, 78.77 cM
• Alliance: Tardbp^{tm1(TARDBP*G348C/Venus)Okn} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:231836
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: A construct containing human TARDBP with point mutations leading to an amino acid change of glycine to cysteine at position 348 (G348C) fused to Venus inserted into exon 2. (J:231836)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tardbp Mutation: 68 strains or lines available

References

• Original: J:231836 Hasegawa M, et al., Analysis of RNA metabolism in peripheral WBCs of TDP-43 KI mice identifies novel biomarkers of ALS. Neurosci Res. 2016 May;106:12-22
• All: 1 reference(s)