Cacna1s^tm1.1Arte
Targeted Allele Detail

Summary

• Symbol: Cacna1s^tm1.1Arte
• Name: calcium channel, voltage-dependent, L type, alpha 1S subunit; targeted mutation 1.1, TaconicArtemis
• MGI ID: MGI:5819113
• Synonyms: CaV1.1^deltaE29
• Gene: Cacna1s Location: Chr1:135980549-136047268 bp, + strand Genetic Position: Chr1, 59.55 cM, cytoband F
• Alliance: Cacna1s^tm1.1Arte page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:235534
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Modified isoform(s))
• Mutation: Intragenic deletion
• Mutation details: A loxP-flanked puromycin selection cassette replaced alternatively spliced exon 29. Cre-mediated recombination deleted the selection cassette, leaving a single loxP site in place of exon 29. Exon 29 is excluded in the transcript expressed in fetal tissues, but is present in the transcript expressed shortly after birth and in adult tissues. (J:235534)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cacna1s Mutation: 118 strains or lines available

References

• Original: J:235534 Sultana N, et al., Restricting calcium currents is required for correct fiber type specification in skeletal muscle. Development. 2016 May 1;143(9):1547-59
• All: 3 reference(s)