Ppp1r8^tm1.1Itl
Targeted Allele Detail

Summary

• Symbol: Ppp1r8^tm1.1Itl
• Name: protein phosphatase 1, regulatory subunit 8; targeted mutation 1.1, inGenious Targeting Laboratory
• MGI ID: MGI:5819241
• Synonyms: Ppp1r8^fl
• Gene: Ppp1r8 Location: Chr4:132554240-132570480 bp, - strand Genetic Position: Chr4, 65.97 cM
• Alliance: Ppp1r8^tm1.1Itl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:238108
• Parent Cell Line: iTL BA1 (ES Cell)
• Strain of Origin: (C57BL/6NTac x 129S6/SvEvTac)F1

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: A 3.74-kb region, encompassing exons 1-2, was flanked by loxP sites and an frt-flanked neomycin resistance cassette. The neo cassette was removed by mating with FLP recombinase-expressing homozygous mice. (J:238108)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ppp1r8 Mutation: 29 strains or lines available

References

• Original: J:238108 Boens S, et al., Brief Report: The Deletion of the Phosphatase Regulator NIPP1 Causes Progenitor Cell Expansion in the Adult Liver. Stem Cells. 2016 Aug;34(8):2256-62
• All: 5 reference(s)