Kcne4^tm1Gwab
Targeted Allele Detail

Summary

• Symbol: Kcne4^tm1Gwab
• Name: potassium voltage-gated channel, Isk-related subfamily, gene 4; targeted mutation 1, Geoffrey W Abbott
• MGI ID: MGI:5819251
• Synonyms: Kcne4^-
• Gene: Kcne4 Location: Chr1:78794628-78797749 bp, + strand Genetic Position: Chr1, 40.89 cM
• Alliance: Kcne4^tm1Gwab page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:227222
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129/Sv

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• The sole coding exon of the gene was replaced with a neomycin selection cassette and LacZ genes. (J:227222)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Kcne4 Mutation: 15 strains or lines available

References

• Original: J:227222 Crump SM, et al., Kcne4 deletion sex- and age-specifically impairs cardiac repolarization in mice. FASEB J. 2016 Jan;30(1):360-9
• All: 2 reference(s)