Lpcat3tm1c(EUCOMM)Wtsi
Targeted Allele Detail
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Symbol: |
Lpcat3tm1c(EUCOMM)Wtsi |
Name: |
lysophosphatidylcholine acyltransferase 3; targeted mutation 1c, Wellcome Trust Sanger Institute |
MGI ID: |
MGI:5822780 |
Synonyms: |
F, Lpcat3fl |
Gene: |
Lpcat3 Location: Chr6:124639887-124681142 bp, + strand Genetic Position: Chr6, 59.17 cM
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Alliance: |
Lpcat3tm1c(EUCOMM)Wtsi page
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IMPC: |
Lpcat3 gene page |
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Mutant Cell Line: |
EPD0455_5_A07 |
Germline Transmission: |
Earliest citation of germline transmission:
J:220827
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Parent Cell Line: |
JM8A1.N3 (ES Cell)
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Strain of Origin: |
C57BL/6N-Atm1Brd
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Project Collection: |
EUCOMM
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Allele Type: |
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Targeted (Conditional ready) |
Mutation: |
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Insertion
Vector: L1L2_Bact_P
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Mutation details: The L1L2_Bact_P cassette was inserted at position 124675731 of Chromosome 6 upstream of the critical exon 3 (Build GRCm39). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. A third loxP site is inserted downstream of the targeted exon 3 at position 124676557. Flp-mediated recombination removed the reporter and selection cassettes and left exon 3 floxed. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml.
(J:220827)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Lpcat3 Mutation: |
26 strains or lines available
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Original: |
J:220827 Rong X, et al., Lpcat3-dependent production of arachidonoyl phospholipids is a key determinant of triglyceride secretion. Elife. 2015;4 |
All: |
5 reference(s) |
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