Tmprss6^hem8
Chemically induced Allele Detail

Summary

• Symbol: Tmprss6^hem8
• Name: transmembrane serine protease 6; haematopoietic 8
• MGI ID: MGI:5822806
• Synonyms: hem^m08Jus
• Gene: Tmprss6 Location: Chr15:78323867-78352834 bp, - strand Genetic Position: Chr15, 37.49 cM, cytoband E2
• Alliance: Tmprss6^hem8 page

Mutation origin

• Strain of Origin: C57BL/6J
• Project Collection: Mutagenesis for Dev. Defects

Mutation description

• Allele Type: Chemically induced (ENU) (Hypomorph)
• Mutation: Single point mutation
• Mutation details: Sequencing of mutant mice revealed an A856T transversion mutation that resulted in an Ile286Phe (I286F) substitution that impaired in vitro protease activity. Ile286 is a highly conserved residue in the first CUB domain of the encoded protein. (J:237155)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tmprss6 Mutation: 46 strains or lines available

References

• Original: J:237155 Bartnikas TB, et al., Identification and characterization of a novel murine allele of Tmprss6. Haematologica. 2013 Jun;98(6):854-61
• All: 1 reference(s)