Paxx^em1Spj
Endonuclease-mediated Allele Detail

Summary

• Symbol: Paxx^em1Spj
• Name: non-homologous end joining factor; endonuclease-mediated mutation 1, Stephen P Jackson
• MGI ID: MGI:5822837
• Synonyms: Paxx^-, Paxx^em1Gb
• Gene: Paxx Location: Chr2:25345153-25351106 bp, - strand Genetic Position: Chr2, 17.27 cM
• Alliance: Paxx^em1Spj page

Small body size, absence of thymus, and small spleen in Paxx^em1Spj/Paxx^em1Spj Nhej1^tm1Fwa/Nhej1^tm1Fwa mice

Show the 4 phenotype image(s) involving this allele.

Mutation origin

• Strain of Origin: C57BL/6NTac

Mutation description

Allele Type: Endonuclease-mediated (Null/knockout) Mutation: Intragenic deletion Mutation details: The mutation is a 1.6-kb deletion of the entire genomic region of the gene. Resulting homozygous mice showed complete absence of the encoded protein in tissues such as thymus, lung, and brain where it is normally highly expressed. (J:236776)

Generation of the Paxx^em1Spj allele

Expression

In Mice Carrying this Mutation:	37 assay results
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Paxx Mutation: 11 strains or lines available

References

• Original: J:236776 Balmus G, et al., Synthetic lethality between PAXX and XLF in mammalian development. Genes Dev. 2016 Oct 1;30(19):2152-2157
• All: 1 reference(s)