Hira^{tm1d(EUCOMM)Wtsi}
Targeted Allele Detail

Summary

• Symbol: Hira^{tm1d(EUCOMM)Wtsi}
• Name: histone cell cycle regulator; targeted mutation 1d, Wellcome Trust Sanger Institute
• MGI ID: MGI:5823078
• Synonyms: Hira^-
• Gene: Hira Location: Chr16:18695787-18789059 bp, + strand Genetic Position: Chr16, 11.69 cM, cytoband A-B1
• Alliance: Hira^{tm1d(EUCOMM)Wtsi} page
• IMPC: Hira gene page

Mutation origin

• Mutant Cell Line: EPD0181_1_A05
• Germline Transmission: Earliest citation of germline transmission: J:231593
• Parent Cell Line: JM8.N4 (ES Cell)
• Strain of Origin: C57BL/6N
• Project Collection: EUCOMM

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion Vector: L1L2_gt1
• Mutation details: Cre-mediated excison of the Hira^{tm1c(EUCOMM)Wtsi} allele resulted in the removal of the loxP flanked critical exon 4. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml. (J:231593)

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hira Mutation: 74 strains or lines available

References

• Original: J:231593 Valenzuela N, et al., Cardiomyocyte-specific conditional knockout of the histone chaperone HIRA in mice results in hypertrophy, sarcolemmal damage and focal replacement fibrosis. Dis Model Mech. 2016 Mar 1;9(3):335-45
• All: 2 reference(s)